DNA & RNA Phosphoramidites:
DNA synthesis products; Cyanoethyl phosphoramidites of deoxy nucleosides. ChemGenes acquired this dominating patent from Applied Biosystems (now a subsidiary of Perkin-Elmer Corp.), Foster City, CA in 1993.
• Patent #4,458,066
• Process for preparing polynucleotides
Abstract
New and useful intermediate nucleotides bound to an inorganic polymer support, including the preparation thereof, and processes for the conversion to oligonucleotides which are especially useful for the synthesis of polynucleotides, particularly ribonucleic (RNA) & deoxyribonucleic acids (DNA).

In addition to the above license, ChemGenes has acquired the license of the second amidite patent from Proligo LLC, Boulder. This is a very broad patent of Biochemicals which are used to produce DNA & RNA with world wide marketing rights.
• Patent # RE 34,069 for Patent #4,725,677
• Process for the preparation of oligonucleotides
Abstract
The invention relates to a process for the preparation of oligonucleotides...the phosphine derivative used is a compound of the general formula III in which X and L can react with OH groups of the sugar units in the oligonucleotides, and R.sup.3 is a protective group which can be liberated by b-elimination.

Products for Antisense Therapeutics:
Cyanoethyl phosphoramidites of ribo nucleosides; ChemGenes is the owner several of 2'-O-Methoxy-RNA phosphoramidite Patents obtained from the U.S. Government. Nevertheless, we are well recognized in the industry for the supply of these products.

• United States Patent # 5,214,135 Srivastava, et al.
• N-protected-2'-O-methyl-ribonucleosides and N-protected 2'-O-methyl-3'-cyanoethyl-N-,N-diisopropyl phosphoramidite ribonucleosides.
Abstract
This invention is directed to improve the process & purity of the above mentioned compounds in excess of 99.8% and up to 99.9%.

• United States Patent # 5,525,719 Srivastava, et al.
• N-protected-2'-O-methyl-and N-protected-3'-O-methyl-ribonucleosides and their phosphoramidite derivatives.
Abstract
This invention is directed to improve processes and for producing high purity for 2’-OMe and 3’-OMe amidites.

• United States Patent # 5,744,595 Srivastava, et al.
• Propargyl modified nucleosides and nucleotides
Abstract
The invention describes a novel 2'-O-alkylation reaction to produce a novel series of nucleosides carrying the 2'-O-propargyl group. The procedure involves novel techniques for regioselective introduction of 2'-/3'-O-propargyl group directly on the 5'-DMT-N-protected- nucleosides. The reaction process has many significant features and leads to isomeric ratios in favor of the 2'-region isomer. This allows the synthesis of the corresponding phosphoramidites of high purity.

• Patent # 5,003,097
• ChemGenes owns a License from the United States government, National Institute of Health (NIH). This License allows us to manufacture sulfurizing reagent, also known as Beaucage reagent.
Abstract
Method for the sulfurization of phosphorous groups in compounds. A method is disclosed for the sulfurization of a phosphorus containing compound.

• United States Patent # 5,013,830
• In addition to the above mentioned 2'-O-Methyl patents, ChemGenes has obtained a license from Ajinomoto Co. Inc., Tokyo, Japan.

DNA & RNA Based Custom Synthesis:
ChemGenes holds a joint patent with Oligos Etc. Wilsonville, OR for Custom DNA & RNA, Oligonucleotide phosphate esters.
• United States Patent # 6,015,886 Srivastava, Dale, et al.
• Oligonucleotide phosphate esters.
Abstract:
This invention relates to synthetic oligonucleotides that are useful for antisense based therapeutic applications. The synthetic oligonucleotides of this invention have modifications in the sugar phosphate backbone for improved antisense properties.