(Applications include Affinity Chromatography & One bead one compound combinatorial libraries)

ChemGenes has developed a non-cleavable support, which is inert in nature and is amenable to oligonucleotide synthesis. Using our irreversible support leads to oligo synthesis of coupling efficiencies of 98-99% per step for a chain length of 20-40 mers.

Our Inert beads are uniform particles. The support bound oligonucleotides, which are irreversibly bound, have extensive applications in molecular biology. Some of the common applications are as follows:

• Affinity based chromatography for oligonucleotides,

proteins, and other macromolecules.
• Design and construction of one bead one compound libraries by split sythesis methods.1
• PCR amplification is possible with the support attached to oligonucleotides. See photo to the right for bead based aptamer library screening, sequencing analysis of PCR products.
• Molecular Biology R&D experiments on bead bound oligonucleotides have performed beyond expectations.

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1. This method has been used by Gorenstein & Coworkers (Xianbin Yang, Suzanne E. Bassett, Xin Li, Bruce A. Luxon, Norbert K. Herzog, Robert E. Shope, Judy Aronson, Tari W. Prow, James F. Leary, Romy Kirby, Andrew D. Ellington, and David G. Gorenstein, Nucleic Acid Research, 2002, vol 30, e 132) for the selection of combinatorial oligonucleotides aptamer and PCR amplification followed by sequencing.